Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells
Identifieur interne : 000308 ( Main/Exploration ); précédent : 000307; suivant : 000309Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells
Auteurs : Xiaoyang Yang [République populaire de Chine] ; Shufang Zhang [République populaire de Chine] ; Denggao Huang [République populaire de Chine] ; Zhiming Wang [République populaire de Chine] ; Xiaoxia Chen [République populaire de Chine] ; Xiansheng Luo [République populaire de Chine] ; Meiqing Lei [République populaire de Chine] ; Feng Yu [République populaire de Chine] ; Xiaobo Chen [République populaire de Chine] ; Peilong Huang [République populaire de Chine]Source :
- The Journal of International Medical Research [ 0300-0605 ] ; 2019.
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. Mesenchymal stem cells (MSCs) generate an immunosuppressive microenvironment by secreting cytokines and have been used to treat autoimmune diseases. We report the first case of refractory secondary HLH treated with umbilical cord MSCs. A 52-year-old Chinese female patient with a history of type 2 diabetes was diagnosed with refractory secondary HLH based upon the HLH-2004 protocol and was treated by infusion of third-party umbilical cord MSCs (1.4 × 106 cells/kg of body weight, 70 × 106 cells in total) from the stem cell bank of Hainan Province. Body temperature recovered to normal on the sixth day after infusion with umbilical cord MSCs, and the levels of inflammatory factors macrophage inflammatory protein (MIP)-1α, interleukin (IL)-12p70, stromal cell-derived factor (SDF)-1α, and IL-7 decreased significantly. Blood glucose levels were significantly lower than before treatment, and the amount of insulin needed was significantly reduced. Umbilical cord MSCs can relieve the symptoms of refractory secondary HLH and have a therapeutic effect on insulin resistance in type 2 diabetes mellitus.
Url:
DOI: 10.1177/0300060519836533
PubMed: 30961409
PubMed Central: 6567783
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000303
- to stream Pmc, to step Curation: 000303
- to stream Pmc, to step Checkpoint: 000272
- to stream Ncbi, to step Merge: 000529
- to stream Ncbi, to step Curation: 000529
- to stream Ncbi, to step Checkpoint: 000529
- to stream Main, to step Merge: 000308
- to stream Main, to step Curation: 000308
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells</title><author><name sortKey="Yang, Xiaoyang" sort="Yang, Xiaoyang" uniqKey="Yang X" first="Xiaoyang" last="Yang">Xiaoyang Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shufang" sort="Zhang, Shufang" uniqKey="Zhang S" first="Shufang" last="Zhang">Shufang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff2-0300060519836533">Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Denggao" sort="Huang, Denggao" uniqKey="Huang D" first="Denggao" last="Huang">Denggao Huang</name><affiliation wicri:level="1"><nlm:aff id="aff2-0300060519836533">Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Zhiming" sort="Wang, Zhiming" uniqKey="Wang Z" first="Zhiming" last="Wang">Zhiming Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xiaoxia" sort="Chen, Xiaoxia" uniqKey="Chen X" first="Xiaoxia" last="Chen">Xiaoxia Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Xiansheng" sort="Luo, Xiansheng" uniqKey="Luo X" first="Xiansheng" last="Luo">Xiansheng Luo</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Lei, Meiqing" sort="Lei, Meiqing" uniqKey="Lei M" first="Meiqing" last="Lei">Meiqing Lei</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Feng" sort="Yu, Feng" uniqKey="Yu F" first="Feng" last="Yu">Feng Yu</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xiaobo" sort="Chen, Xiaobo" uniqKey="Chen X" first="Xiaobo" last="Chen">Xiaobo Chen</name><affiliation wicri:level="1"><nlm:aff id="aff3-0300060519836533">Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Peilong" sort="Huang, Peilong" uniqKey="Huang P" first="Peilong" last="Huang">Peilong Huang</name><affiliation wicri:level="1"><nlm:aff id="aff3-0300060519836533">Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30961409</idno><idno type="pmc">6567783</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567783</idno><idno type="RBID">PMC:6567783</idno><idno type="doi">10.1177/0300060519836533</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000303</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000303</idno><idno type="wicri:Area/Pmc/Curation">000303</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000303</idno><idno type="wicri:Area/Pmc/Checkpoint">000272</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000272</idno><idno type="wicri:Area/Ncbi/Merge">000529</idno><idno type="wicri:Area/Ncbi/Curation">000529</idno><idno type="wicri:Area/Ncbi/Checkpoint">000529</idno><idno type="wicri:doubleKey">0300-0605:2019:Yang X:treatment:of:refractory</idno><idno type="wicri:Area/Main/Merge">000308</idno><idno type="wicri:Area/Main/Curation">000308</idno><idno type="wicri:Area/Main/Exploration">000308</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells</title><author><name sortKey="Yang, Xiaoyang" sort="Yang, Xiaoyang" uniqKey="Yang X" first="Xiaoyang" last="Yang">Xiaoyang Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shufang" sort="Zhang, Shufang" uniqKey="Zhang S" first="Shufang" last="Zhang">Shufang Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff2-0300060519836533">Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Denggao" sort="Huang, Denggao" uniqKey="Huang D" first="Denggao" last="Huang">Denggao Huang</name><affiliation wicri:level="1"><nlm:aff id="aff2-0300060519836533">Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Zhiming" sort="Wang, Zhiming" uniqKey="Wang Z" first="Zhiming" last="Wang">Zhiming Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xiaoxia" sort="Chen, Xiaoxia" uniqKey="Chen X" first="Xiaoxia" last="Chen">Xiaoxia Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Luo, Xiansheng" sort="Luo, Xiansheng" uniqKey="Luo X" first="Xiansheng" last="Luo">Xiansheng Luo</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Lei, Meiqing" sort="Lei, Meiqing" uniqKey="Lei M" first="Meiqing" last="Lei">Meiqing Lei</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Feng" sort="Yu, Feng" uniqKey="Yu F" first="Feng" last="Yu">Feng Yu</name><affiliation wicri:level="1"><nlm:aff id="aff1-0300060519836533">Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Hematology, Affiliated Haikou Hospital Xiangya School Central South University & Haikou Municipal People’s Hospital, Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xiaobo" sort="Chen, Xiaobo" uniqKey="Chen X" first="Xiaobo" last="Chen">Xiaobo Chen</name><affiliation wicri:level="1"><nlm:aff id="aff3-0300060519836533">Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Peilong" sort="Huang, Peilong" uniqKey="Huang P" first="Peilong" last="Huang">Peilong Huang</name><affiliation wicri:level="1"><nlm:aff id="aff3-0300060519836533">Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Stem cell bank of Hainan Province & Hainan Heze Biotechnology Co., Ltd., Haikou</wicri:regionArea><wicri:noRegion>Haikou</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of International Medical Research</title><idno type="ISSN">0300-0605</idno><idno type="eISSN">1473-2300</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. Mesenchymal stem cells (MSCs) generate an immunosuppressive microenvironment by secreting cytokines and have been used to treat autoimmune diseases. We report the first case of refractory secondary HLH treated with umbilical cord MSCs. A 52-year-old Chinese female patient with a history of type 2 diabetes was diagnosed with refractory secondary HLH based upon the HLH-2004 protocol and was treated by infusion of third-party umbilical cord MSCs (1.4 × 10<sup>6</sup> cells/kg of body weight, 70 × 10<sup>6</sup> cells in total) from the stem cell bank of Hainan Province. Body temperature recovered to normal on the sixth day after infusion with umbilical cord MSCs, and the levels of inflammatory factors macrophage inflammatory protein (MIP)-1α, interleukin (IL)-12p70, stromal cell-derived factor (SDF)-1α, and IL-7 decreased significantly. Blood glucose levels were significantly lower than before treatment, and the amount of insulin needed was significantly reduced. Umbilical cord MSCs can relieve the symptoms of refractory secondary HLH and have a therapeutic effect on insulin resistance in type 2 diabetes mellitus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bergsten, E" uniqKey="Bergsten E">E Bergsten</name></author><author><name sortKey="Horne, A" uniqKey="Horne A">A Horne</name></author><author><name sortKey="Arico, M" uniqKey="Arico M">M Arico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marsh, Ra" uniqKey="Marsh R">RA Marsh</name></author><author><name sortKey="Jordan, Mb" uniqKey="Jordan M">MB Jordan</name></author><author><name sortKey="Talano, Ja" uniqKey="Talano J">JA Talano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mougiakakos, D" uniqKey="Mougiakakos D">D Mougiakakos</name></author><author><name sortKey="Machaczka, M" uniqKey="Machaczka M">M Machaczka</name></author><author><name sortKey="Jitschin, R" uniqKey="Jitschin R">R Jitschin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wysocki, Ca" uniqKey="Wysocki C">CA. Wysocki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccarthy, Lc" uniqKey="Mccarthy L">LC McCarthy</name></author><author><name sortKey="Fernandez, Ks" uniqKey="Fernandez K">KS Fernandez</name></author><author><name sortKey="Antony, R" uniqKey="Antony R">R. Antony</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sepulveda, Fe" uniqKey="Sepulveda F">FE Sepulveda</name></author><author><name sortKey="De Saint Basile, G" uniqKey="De Saint Basile G">G. de Saint Basile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Filipovich, A" uniqKey="Filipovich A">A Filipovich</name></author><author><name sortKey="Mcclain, K" uniqKey="Mcclain K">K McClain</name></author><author><name sortKey="Grom, A" uniqKey="Grom A">A. Grom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Risma, K" uniqKey="Risma K">K Risma</name></author><author><name sortKey="Jordan, Mb" uniqKey="Jordan M">MB. Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishii, E" uniqKey="Ishii E">E Ishii</name></author><author><name sortKey="Ueda, I" uniqKey="Ueda I">I Ueda</name></author><author><name sortKey="Shirakawa, R" uniqKey="Shirakawa R">R Shirakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dalal, Bi" uniqKey="Dalal B">BI Dalal</name></author><author><name sortKey="Vakil, Ap" uniqKey="Vakil A">AP Vakil</name></author><author><name sortKey="Khare, Ns" uniqKey="Khare N">NS Khare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slostad, J" uniqKey="Slostad J">J Slostad</name></author><author><name sortKey="Hoversten, P" uniqKey="Hoversten P">P Hoversten</name></author><author><name sortKey="Haddox, Cl" uniqKey="Haddox C">CL Haddox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Fakih, R" uniqKey="El Fakih R">R El Fakih</name></author><author><name sortKey="Mohamed, Sy" uniqKey="Mohamed S">SY Mohamed</name></author><author><name sortKey="Alnounou, R" uniqKey="Alnounou R">R Alnounou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotas, Me" uniqKey="Kotas M">ME Kotas</name></author><author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA. Matthay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohr, A" uniqKey="Mohr A">A Mohr</name></author><author><name sortKey="Zwacka, R" uniqKey="Zwacka R">R. Zwacka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Huang, M" uniqKey="Huang M">M Huang</name></author><author><name sortKey="Zhao, R" uniqKey="Zhao R">R Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mai, S" uniqKey="Mai S">S Mai</name></author><author><name sortKey="Zou, L" uniqKey="Zou L">L Zou</name></author><author><name sortKey="Tian, X" uniqKey="Tian X">X Tian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cantore, S" uniqKey="Cantore S">S Cantore</name></author><author><name sortKey="Crincoli, V" uniqKey="Crincoli V">V Crincoli</name></author><author><name sortKey="Boccaccio, A" uniqKey="Boccaccio A">A Boccaccio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kruk, D" uniqKey="Kruk D">D Kruk</name></author><author><name sortKey="Heijink, Ih" uniqKey="Heijink I">IH Heijink</name></author><author><name sortKey="Slebos, Dj" uniqKey="Slebos D">DJ Slebos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kadry, Sm" uniqKey="Kadry S">SM Kadry</name></author><author><name sortKey="El Dakdoky, Mh" uniqKey="El Dakdoky M">MH El-Dakdoky</name></author><author><name sortKey="Haggag, Nz" uniqKey="Haggag N">NZ Haggag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deng, Z" uniqKey="Deng Z">Z Deng</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Xiaoyang" sort="Yang, Xiaoyang" uniqKey="Yang X" first="Xiaoyang" last="Yang">Xiaoyang Yang</name></noRegion><name sortKey="Chen, Xiaobo" sort="Chen, Xiaobo" uniqKey="Chen X" first="Xiaobo" last="Chen">Xiaobo Chen</name><name sortKey="Chen, Xiaoxia" sort="Chen, Xiaoxia" uniqKey="Chen X" first="Xiaoxia" last="Chen">Xiaoxia Chen</name><name sortKey="Huang, Denggao" sort="Huang, Denggao" uniqKey="Huang D" first="Denggao" last="Huang">Denggao Huang</name><name sortKey="Huang, Peilong" sort="Huang, Peilong" uniqKey="Huang P" first="Peilong" last="Huang">Peilong Huang</name><name sortKey="Lei, Meiqing" sort="Lei, Meiqing" uniqKey="Lei M" first="Meiqing" last="Lei">Meiqing Lei</name><name sortKey="Luo, Xiansheng" sort="Luo, Xiansheng" uniqKey="Luo X" first="Xiansheng" last="Luo">Xiansheng Luo</name><name sortKey="Wang, Zhiming" sort="Wang, Zhiming" uniqKey="Wang Z" first="Zhiming" last="Wang">Zhiming Wang</name><name sortKey="Yu, Feng" sort="Yu, Feng" uniqKey="Yu F" first="Feng" last="Yu">Feng Yu</name><name sortKey="Zhang, Shufang" sort="Zhang, Shufang" uniqKey="Zhang S" first="Shufang" last="Zhang">Shufang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000308 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000308 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6567783
|texte= Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30961409" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |